TNFRSF18 / GITR (26-162, His-tag) Human Protein
CAT#: AR51970PU-N
TNFRSF18 / GITR (26-162, His-tag) human protein, 0.25 mg
Size: 50 ug
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CNY 17,930.00
货期*
详询
规格
Cited in 1 publication. |
Specifications
Product Data | |
Species | Human |
Expression Host | Insect |
Expression cDNA Clone or AA Sequence |
QRPTGGPGCG PGRLLLGTGT DARCCRVHTT RCCRDYPGEE CCSEWDCMCV QPEFHCGDPC CTTCRHHPCP PGQGVQSQGK FSFGFQCIDC ASGTFSGGHE GHCKPWTDCT QFGFLTVFPG NKTHNAVCVP GSPPAEPLEH HHHHH
|
Tag | His-tag |
Predicted MW | 15.6 kDa |
Concentration | lot specific |
Purity | >95% by SDS - PAGE |
Buffer | Presentation State: Purified State: Liquid purified protein Buffer System: Phosphate Buffered Saline (pH 7.4) containing 10% glycerol. |
Preparation | Liquid purified protein |
Storage | Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Endotoxin | < 1.0 EU per 1 microgram of protein (determined by LAL method) |
Reference Data | |
RefSeq | NP_004186 |
Locus ID | 8784 |
UniProt ID | Q9Y5U5 |
Cytogenetics | 1p36.33 |
Synonyms | AITR; CD357; ENERGEN; GITR; GITR-D |
Summary | This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011] |
Protein Families | Druggable Genome, Secreted Protein, Transmembrane |
Protein Pathways | Cytokine-cytokine receptor interaction |
Citations (1)
The use of this Proteins has been cited in the following citations: |
---|
Novel Tumor Suppressor Function of Glucocorticoid-Induced TNF Receptor GITR in Multiple Myeloma
,null,
PLoS ONE
,PubMed ID 23785514
[TNFRSF18]
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