TOM1L2 (1-507, His-tag) Human Protein

Specifications

Product Data
Species	Human
Expression Host	E. coli
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) MGSSHHHHHH SSGLVPRGSH MGSEFMEFLL GNPFSTPVGQ CLEKATDGSL QSEDWTLNME ICDIINETEE GPKDAIRALK KRLNGNRNYR EVMLALTVLE TCVKNCGHRF HILVANRDFI DSVLVKIISP KNNPPTIVQD KVLALIQAWA DAFRSSPDLT GVVHIYEELK RKGVEFPMAD LDALSPIHTP QRSVPEVDPA ATMPRSQSQQ RTSAGSYSSP PPAPYSAPQA PALSVTGPIT ANSEQIARLR SELDVVRGNT KVMSEMLTEM VPGQEDSSDL ELLQELNRTC RAMQQRIVEL ISRVSNEEVT EELLHVNDDL NNVFLRYERF ERYRSGRSVQ NASNGVLNEV TEDNLIDLGP GSPAVVSPMV GNTAPPSSLS SQLAGLDLGT ESVSGTLSSL QQCNPRDGFD MFAQTRGNSL AEQRKTVTYE DPQAVGGLAS ALDNRKQSSE GIPVAQPSVM DDIEVWLRTD LKGDDLEEGV TSEEFDKFLE ERAKAAEMVP DLPSPPMEAP APASNPSGRK KPERSEDALF AL
Tag	His-tag
Predicted MW	58.2 kDa
Concentration	lot specific
Purity	>80% by SDS - PAGE
Buffer	Presentation State: Purified State: Liquid purified protein Buffer System: Phosphate buffered saline (pH 7.4) containing 10% glycerol, 1 mM DTT
Preparation	Liquid purified protein
Storage	Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing.
Stability	Shelf life: one year from despatch.
Reference Data
RefSeq	NP_001028723
Locus ID	146691
UniProt ID	Q6ZVM7, Q6ZVM7-2
Cytogenetics	17p11.2
Summary	This gene belongs to a small gene family whose members have an N-terminal VHS domain followed by a GAT domain; domains which typically participate in vesicular trafficking. The canonical protein encoded by this gene also has a C-terminal clathrin binding motif. This protein has been shown to interact with Tollip, clathrin and ubiquitin and is thought to play a role in endosomal sorting. This gene resides in the 3.7 Mb deletion of chromosome region 17p11.2 that is associated with Smith-Magenis syndrome. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Apr 2017]

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