ZFAND1 (1-268, His-tag) Human Protein
CAT#: AR50902PU-S
ZFAND1 (1-268, His-tag) human recombinant protein, 50 µg
Size: 250 ug
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CNY 8,900.00
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规格
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
MGSSHHHHHH SSGLVPRGSH MGSMAELDIG QHCQVEHCRQ RDFLPFVCDD CSGIFCLEHR SRESHGCPEV TVINERLKTD QHTSYPCSFK DCAERELVAV ICPYCEKNFC LRHRHQSDHE CEKLEIPKPR MAATQKLVKD IIDSKTGETA SKRWKGAKNS ETAAKVALMK LKMHADGDKS LPQTERIYFQ VFLPKGSKEK SKPMFFCHRW SIGKAIDFAA SLARLKNDNN KFTAKKLRLC HITSGEALPL DHTLETWIAK EDCPLYNGGN IILEYLNDEE QFCKNVESYL E
|
Tag | His-tag |
Predicted MW | 33.2 kDa |
Concentration | lot specific |
Purity | >90% by SDS - PAGE |
Buffer | Presentation State: Purified State: Liquid purified protein Buffer System: 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1 mM DTT |
Preparation | Liquid purified protein |
Protein Description | Recombinant human ZFAND1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
Storage | Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Reference Data | |
RefSeq | NP_001164267 |
Locus ID | 79752 |
UniProt ID | Q8TCF1 |
Cytogenetics | 8q21.13 |
Summary | Plays a role in the regulation of cytoplasmic stress granules (SGs) turnover. SGs are dynamic and transient cytoplasmic ribonucleoprotein assemblies important for cellular protein homeostasis when protein production is suspended after acute exogenous stress (PubMed:29804830). Associates with SGs and is involved in the efficient and specific arsenite-induced clearance process of SGs through the recruitment of the ubiquitin-selective ATPase VCP and the 26S proteasome (PubMed:29804830). This process requires both complexes for efficient degradation of damaged ubiquitinated SG proteins during recovery from arsenite stress, and hence avoiding aberrant cytoplasmic SGs degradation via autophagy (PubMed:29804830).[UniProtKB/Swiss-Prot Function] |
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