CXCL11 / ITAC (22-94, His-tag) Human Protein
CAT#: AR50121PU-N
CXCL11 / ITAC (22-94, His-tag) human recombinant protein, 0.5 mg
Size: 100 ug
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CNY 14,920.00
货期*
详询
规格
Cited in 1 publication. |
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
MGSSHHHHHH SSGLVPRGSH MFPMFKRGRC LCIGPGVKAV KVADIEKASI MYPSNNCDKI EVIITLKENK GQRCLNPKSK QARLIIKKVE RKNF
|
Tag | His-tag |
Predicted MW | 10.6 kDa |
Concentration | lot specific |
Purity | >90% by SDS - PAGE |
Buffer | Presentation State: Purified State: Liquid purified protein Buffer System: 10 mM sodium citrate (pH 3.5), 20% glycerol, 2 mM DTT |
Preparation | Liquid purified protein |
Protein Description | Recombinant human CXCL11 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer. |
Storage | Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Endotoxin | < 1.0 EU per 1 microgram of protein (determined by LAL method) |
Reference Data | |
RefSeq | NP_001289052 |
Locus ID | 6373 |
UniProt ID | O14625 |
Cytogenetics | 4q21.1 |
Synonyms | b-R1; H174; I-TAC; IP-9; IP9; SCYB9B; SCYB11 |
Summary | Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This antimicrobial gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014] |
Protein Families | Druggable Genome, Secreted Protein, Transmembrane |
Protein Pathways | Chemokine signaling pathway, Cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway |
Citations (1)
The use of this Proteins has been cited in the following citations: |
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Endothelial cells under therapy-induced senescence secrete CXCL11, which increases aggressiveness of breast cancer cells.
,null,
Cancer letters
,PubMed ID 32659248
[CXCL11]
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