Interleukin-24 / IL24 (His-tag) Human Protein

Specifications

Product Data
Species	Human
Expression Host	CHO
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) QEFHFGPCQV KGVVPQKLWE AFWAVKDTMQ AQDNITSARL LQQEVL QNVS DAESCYLVHT LLEFYLKTVF KNYHNRTVEV RTLKSFSTLA N NFVLIVSQL QPSQENEMFS IRDSAHRRFL LFRRAFKQLD VEAALTK ALG EVDILLTWMQ KFYKLHHHHHH
Tag	His-tag
Predicted MW	18.9 kDa
Purity	>95% by SDS-PAGE and HPLC
Buffer	Presentation State: Purified State: Lyophilized purified protein Stabilizer: None
Preparation	Lyophilized purified protein
Protein Description	Recombinant Human IL-24 is an 18.9 kDa glycoprotein, containing 161 amino acid residues, including a C-terminal His-tag.
Storage	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month  or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Stability	Shelf life: one year from despatch.
Endotoxin	< 0.1 ng per µg of IL-24
Reference Data
RefSeq	NP_001172085
Locus ID	11009
UniProt ID	Q13007
Cytogenetics	1q32.1
Synonyms	IL-24, MDA7, ST16
Summary	This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

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