Malcavernin (His-tag) Human Protein
CAT#: AR26003PU-N
Malcavernin (His-tag) human recombinant protein, 20 µg
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CNY 4,030.00
货期*
7周
规格
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Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
MGSSHHHHHH SSGLVPRGSH MEEEGKKGKK PGIVSPFKRV FLKGEKSRDK KAHEKVTERR PLHTVVLSLP ERVEPDRLLS DYIEKEVKYL GQLTSIPGYL NPSSRTEILH FIDNAKRAHQ LPGHLTQHDA VLSLSAYNVK LAWRDGEDII LRVPIHDIAA VSYVRDDAAH LVVLKTAQDP GISPSQSLCA ESSRGLSAGS LSESAVGPVE ACCLVILAAE SKVAAEELCC LLGQVFQVVY TESTIDFLDR AIFDASTPTH HLSLHSDDSS TKVDIKETYE VEASTFCFPE SVDVGGASPH SKTISESELS ASATELLQDY MLTLRTKLSS QEIQQFAALL HEYRNGASIH EFCINLRQLY GDSRKFLLLG LRPFIPEKDS QFENFLETIG VKDGRGIITD SFGRHRRALS TTSSSTTNGN RATGSSDDRS APSEGDEWDR MISDISSDIE ALGCSMDQDS A
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Tag | His-tag |
Purity | >95% by SDS-PAGE and silver stain |
Buffer | Presentation State: Purified State: Lyophilized protein Buffer System: PBS |
Preparation | Lyophilized protein |
Protein Description | Human recombinant Malcavernin (fragment), aa sequence: 464 |
Note | Protein RefSeq: NM_001029835.2 mRNA RefSeq: NM_001029835.2 |
Storage | Lyophilized samples are stable for six months at –20°C to –70°C. Reconstituted protein should be stored in working aliquots at -20°C. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Endotoxin | < 0.1 ng/µg of CCM-2 |
Reference Data | |
RefSeq | NP_001025006 |
Locus ID | 83605 |
UniProt ID | Q9BSQ5 |
Cytogenetics | 7p13 |
Synonyms | CCM2, C7orf22, PP10187 |
Summary | This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009] |
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