KRIT1 / CCM1 (His-tag) Human Protein

Specifications

Product Data
Species	Human
Expression Host	E. coli
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) MLLKEAINKP YEKVRIYRMD GSYRSVELKH GNNTTVQQIM EGMRLSQETQ QYFTIWICSE NLSLQLKPYH KPLQHVRDWP EILAELTNLD PQRETPQLFL RRDVRLPLEV EKQIEDPLAI LILFDEARYN LLKGFYTAPD AKLITLASLL LQIVYGNYES KKHKQGFLNE ENLKSIVPVT KLKSKAPHWT NRILHEYKNL STSEGVSKEM HHLQRMFLQN CWEIPTYGAA FFTGQIFTKA SPSNHKVIPV YVGVNIKGLH LLNMETKALL ISLKYGCFMW QLGDTDTCFQ IHSMENKMSF IVHTKQAGLV VKLLMKLNGQ LMPTERNSLE HHHHH
Tag	His-tag
Predicted MW	39 kDa
Purity	>90% by SDS-PAGE and silver stain
Buffer	Presentation State: Purified State: Lyophilized protein Buffer System: 30 mM NaCl, 50 mM NaP, pH 7.4 Stabilizer: None
Preparation	Lyophilized protein
Protein Description	Recombinant Human recombinant CCM-1/Krit1, aa. 718
Note	Protein RefSeq: NM_004912 mRNA RefSeq: NM_194456.1
Storage	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month  or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Stability	Shelf life: one year from despatch.
Endotoxin	< 0.1 ng/µg of CCM-1
Reference Data
RefSeq	NP_001013424
Locus ID	889
UniProt ID	O00522
Cytogenetics	7q21.2
Synonyms	CAM; CCM1
Summary	This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]
Protein Families	Druggable Genome

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