VAMP-2 / Synaptobrevin-2 (1-89, His-tag) Human Protein
CAT#: AR09091PU-L
VAMP-2 / Synaptobrevin-2 (1-89, His-tag) human protein, 0.5 mg
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CNY 14,920.00
货期*
详询
规格
Cited in 3 publications. |
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMSA TAATAPPAAP AGEGGPPAPP PNLTSNRRLQ QTQAQVDEVV DIMRVNVDKV LERDQKLSEL DDRADALQAG ASQFETSAAKLKRKYW
|
Tag | His-tag |
Predicted MW | 13.8 kDa |
Concentration | lot specific |
Purity | ≥95 by SDS PAGE |
Buffer | Presentation State: Purified State: Liquid purified protein Buffer System: PBS, pH 7.4, 1 mM EDTA |
Preparation | Liquid purified protein |
Protein Description | Synaptobrevin 2, amino acids 1-89, fused to His-tag was expressed in E.coli. |
Storage | Store (in aliquots) at -20°C. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Reference Data | |
RefSeq | NP_001317054 |
Locus ID | 6844 |
UniProt ID | F8WCA0 |
Cytogenetics | 17p13.1 |
Synonyms | NEDHAHM; SYB2; VAMP-2 |
Summary | The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. [provided by RefSeq, Jul 2008] |
Protein Families | Druggable Genome, Secreted Protein, Transmembrane |
Protein Pathways | SNARE interactions in vesicular transport |
Citations (3)
The use of this Proteins has been cited in the following citations: |
---|
Syntaxin-1/TI-VAMP SNAREs interact with Trk receptors and are required for neurotrophin-dependent outgrowth
,null,
Oncotarget
,PubMed ID 30542508
[VAMP2]
|
SNAREs Interact with Retinal Degeneration Slow and Rod Outer Segment Membrane Protein-1 during Conventional and Unconventional Outer Segment Targeting
,null,
PLoS ONE
,PubMed ID 26406599
[VAMP2]
|
v-SNARE cellubrevin is required for basolateral sorting of AP-1B-dependent cargo in polarized epithelial cells
,null,
The Journal of Cell Biology
,PubMed ID 17485489
[VAMP2]
|
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