IRF1 (1-114, His-tag) Human Protein

Specifications

Product Data
Species	Human
Expression Host	E. coli
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) MGSSHHHHHH SSGLVPRGSH MPITRMRMRP WLEMQINSNQ IPGLIWINKE EMIFQIPWKH AAKHGWDINK DACLFRSWAI HTGRYKAGEK EPDPKTWKAN FRCAMNSLPD IEEVKDQSRN KGSSAVRVYR MLPP
Tag	His-tag
Concentration	lot specific
Purity	≥90 by SDS-PAGE
Buffer	Presentation State: Purified State: Liquid purified protein Buffer System: 20 mM Tris 8.0, 10% glycerol
Preparation	Liquid purified protein
Protein Description	Recombinant human IRF1, fused to His-tag, was expressed in E.coli and purified by using conventional chromatography techniques.
Storage	Store (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Stability	Shelf life: one year from despatch.
Reference Data
RefSeq	NP_001341853
Locus ID	3659
Cytogenetics	5q31.1
Synonyms	IRF-1; MAR
Summary	The protein encoded by this gene is a transcriptional regulator and tumor suppressor, serving as an activator of genes involved in both innate and acquired immune responses. The encoded protein activates the transcription of genes involved in the body's response to viruses and bacteria, playing a role in cell proliferation, apoptosis, the immune response, and DNA damage response. This protein represses the transcription of several other genes. As a tumor suppressor, it both suppresses tumor cell growth and stimulates an immune response against tumor cells. Defects in this gene have been associated with gastric cancer, myelogenous leukemia, and lung cancer. [provided by RefSeq, Aug 2017]
Protein Families	Druggable Genome, Transcription Factors

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