SHBG Human Protein

Specifications

Product Data
Species	Human
Purity	>90% by SDS PAGE
Buffer	Presentation State: Purified State: Lyophilized purified protein Buffer System: 0.02M NH4HCO3
Preparation	Lyophilized purified protein
Applications	Immunoassay.
Protein Description	This protein is a sex hormone binding globulin, is a 45 kDa plasma glycoprotein dimer. It is an androgen transport protein which binds and regulates the free concentration of steroid hormones and is involved in steroid signalling at the cell membrane.
Storage	Store the protein undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Stability	Shelf life: one year from despatch.
Reference Data
RefSeq	NP_001031
Locus ID	6462
UniProt ID	P04278
Cytogenetics	17p13.1
Synonyms	Sex hormone-binding globulin, SHBG, Sex steroid-binding protein, SBP, ABP, TeBG
Summary	This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein transports androgens and estrogens in the blood, binding each steroid molecule as a dimer formed from identical or nearly identical monomers. Polymorphisms in this gene have been associated with polycystic ovary syndrome and type 2 diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Protein Families	Immunoassay.

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