Toxoplasma gondii p30 (45-198) Protozoan Protein

Specifications

Product Data
Species	Protozoan
Concentration	lot specific
Purity	>95% as determined by 10% PAGE (coomassie staining)
Buffer	State: Liquid purified protein Buffer System: 50 mM TRIS-HCl containing 1.5 M Urea and 50% glycerol
Preparation	Liquid purified protein
Applications	ELISA. Western Blot.
Protein Description	This protein is E. coli derived, recombinant Toxoplasma gondii P30 (sag1) immunodominant region supplied as liquid.
Storage	Store the protein at -20°C. Avoid repeated freezing and thawing.
Stability	Shelf life: one year from despatch.
Reference Data
Synonyms	Major surface antigen p30
Summary	Toxoplasma gondii p30 is the immunodominant surface antigen of Toxoplasma gondii. Toxoplasma gondii is an obligate intracellular protozoan that belongs to the class Sporozoa, and the order Eucoccidia. The parasite has an extremely wide host range and is also nonspecific with respect to the kind of cell type it can enter, making it an interesting model to study invasion. Although toxoplasmosis in healthy adults is generally asymptomatic, it produces severe disease in neonates and immunocompromised people, being the cause of death in many AIDS patients. P30 is the major surface antigen of T. gondii. It is a very abundant protein, conserved in most strains, and present both in the vesicular network of the parasitophorous vacuole and on the surface of the parasite. It is very immunogenic, eliciting high titers of antibodies in infected individuals. The gene coding for P30 has been cloned and completely sequenced: the deduced amino acid sequence shows a putative signal sequence at the N terminus, consistent with localization of P30 on the parasite’s surface, as well as a short hydrophobic stretch at the C terminus.
Protein Families	ELISA. Western Blot.

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