Transthyretin / Prealbumin Human Protein
CAT#: AR05083PU-N
Transthyretin / Prealbumin human protein, 1 mg
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CNY 5,740.00
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Specifications
Product Data | |
Species | Human |
Purity | 96% SDS-PAGE confirms prealbumin as the major component. Under certain conditions dimer and monomer subunits can be seen. Cellulose acetate electrophoresis shows one band only with a higher electrophoretic mobility than albumin. |
Buffer | Presentation State: Purified State: Lyophilized purified protein Buffer System: 0.02 M Ammonium Bicarbonate buffer |
Preparation | Lyophilized purified protein |
Applications | ELISA. |
Protein Description | Native Prealbumin from human serum. |
Note | Caution: (A full Health and Safety assessment is available upon request) The serum used to prepare this product has been tested and found to be negative for HIV 1 and 2 antibodies, HBsAg and HCV antibodies. Finished product is negative for HIV antigen P24. |
Storage | Prior to and following reconstitution store the protein at 2-8°C. DO NOT FREEZE! |
Stability | Shelf life: one year from despatch. |
Reference Data | |
RefSeq | NP_000362 |
Locus ID | 7276 |
UniProt ID | P02766, E9KL36 |
Cytogenetics | 18q12.1 |
Synonyms | ATTR; CTS; CTS1; HEL111; HsT2651; PALB; TBPA; TTN |
Summary | This gene encodes one of the three prealbumins, which include alpha-1-antitrypsin, transthyretin and orosomucoid. The encoded protein, transthyretin, is a homo-tetrameric carrier protein, which transports thyroid hormones in the plasma and cerebrospinal fluid. It is also involved in the transport of retinol (vitamin A) in the plasma by associating with retinol-binding protein. The protein may also be involved in other intracellular processes including proteolysis, nerve regeneration, autophagy and glucose homeostasis. Mutations in this gene are associated with amyloid deposition, predominantly affecting peripheral nerves or the heart, while a small percentage of the gene mutations are non-amyloidogenic. The mutations are implicated in the etiology of several diseases, including amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis and carpal tunnel syndrome. [provided by RefSeq, Aug 2017] |
Protein Families | ES Cell Differentiation/IPS, Secreted Protein |
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