Neuropeptide Y / NPY Human Protein
CAT#: AR05070PU-N
Neuropeptide Y / NPY human protein, 0.1 mg
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CNY 4,960.00
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规格
Cited in 3 publications. |
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Specifications
Product Data | |
Species | Human |
Expression cDNA Clone or AA Sequence |
Y-P-S-K-P-D-N-P-G-E-D-A-P-A-E-D-M-A-R-Y-Y-S-A-L-R-H-Y-I-N-L-I-T-R-Q-R-Y-NH2
|
Concentration | lot specific |
Purity | >97% pure by HPLC |
Buffer | Presentation State: Purified State: Liquid purified synthetic peptide Preservative: None Stabilizer: None |
Preparation | Liquid purified synthetic peptide |
Applications | ELISA. |
Protein Description | Synthetic Human Neuropeptide Tyrosine prepared by solid phase synthesis. |
Storage | Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Reference Data | |
RefSeq | NP_000896 |
Locus ID | 4852 |
UniProt ID | P01303, A4D158 |
Cytogenetics | 7p15.3 |
Synonyms | PYY4 |
Summary | This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014] |
Protein Families | Druggable Genome, Secreted Protein, Transmembrane |
Protein Pathways | Adipocytokine signaling pathway |
Citations (3)
The use of this Proteins has been cited in the following citations: |
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Sensory neurons in the human jugular ganglion
,null,
Tissue and Cell
,PubMed ID 32473709
[NPY]
|
Homozygous Truncating Variants in TBC1D23 Cause Pontocerebellar Hypoplasia and Alter Cortical Development
,null,
American Journal of Human Genetics
,PubMed ID 28823707
[NPY]
|
Mechanisms by which the orexigen NPY regulates anorexigenic ?-MSH and TRH
,null,
American Journal of Physiology - Endocrinology and Metabolism
,PubMed ID 23321476
[NPY]
|
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