HSPA8 / HSC70 (active) Human Protein
CAT#: AR03020PU-L
HSPA8 / HSC70 (active) human recombinant protein, 2x0.1 mg
Size: 50 ug
Need it in bulk or customized? Get a free quote |
CNY 9,340.00
货期*
详询
规格
Cited in 8 publications. |
Product images
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Concentration | lot specific |
Purity | >90% pure as determined by SDS-PAGE analysis. |
Buffer | Presentation State: Aff - Purified State: Liquid affinity purified protein Buffer System: Na-Phosphate, pH 7.5 (20 mM), 150 mM NaCl, 10% Glycerol, 200 mM Imidazole. |
Preparation | Liquid affinity purified protein |
Applications | ATPase Assay, WB control, Binding Assays, ELISA reference standard. This protein has ATPase activity at the time of manufacture of 3.2 uM phosphate liberated/hr/ug protein in a 200 uL reaction at 37 C (pH 7.5) in the presence of 20 uL of 1 mM ATP using a Malachite Green assay. |
Protein Description | Recombinant Human Hsc70 Protein with ATPase activity, his-tagged |
Storage | Store the antibody (in aliquots) at -20°C. Can be shipped at 2-8 °C. Avoid repeated freezing and thawing. |
Stability | Shelf life: One year from despatch. |
Reference Data | |
RefSeq | NP_006588 |
Locus ID | 3312 |
UniProt ID | P11142, V9HW22, Q53HF2 |
Cytogenetics | 11q24.1 |
Synonyms | HEL-33; HEL-S-72p; HSC54; HSC70; HSC71; HSP71; HSP73; HSPA10; LAP-1; LAP1; NIP71 |
Summary | This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] |
Protein Families | Stem cell - Pluripotency |
Protein Pathways | Antigen processing and presentation, Endocytosis, MAPK signaling pathway, Spliceosome |
Citations (8)
The use of this Proteins has been cited in the following citations: |
---|
A micropeptide encoded by lncRNA MIR155HG suppresses autoimmune inflammation via modulating antigen presentation
,null,
Science Advances
,PubMed ID 32671205
[HSPA8]
|
DnaJ/Hsc70 chaperone complexes control the extracellular release of neurodegenerative‐associated proteins
,null,
The EMBO Journal
,PubMed ID 27261198
[HSPA8]
|
The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics
,null,
Human Molecular Genetics
,PubMed ID 25882706
[HSPA8]
|
Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone Complement *
,null,
The Journal of Biological Chemistry
,PubMed ID 25864199
[HSPA8]
|
Induction of heat shock protein HSPA6 (HSP70B') upon HSP90 inhibition in cancer cell lines.
,null,
FEBS letters
,PubMed ID 25957766
[HSPA8]
|
Imbalance of Hsp70 family variants fosters tau accumulation
,null,
The FASEB Journal
,PubMed ID 23271055
[HSPA8]
|
Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau
,null,
Biological psychiatry
,PubMed ID 23607970
[HSPA8]
|
The Human TPR Protein TTC4 Is a Putative Hsp90 Co-Chaperone Which Interacts with CDC6 and Shows Alterations in Transformed Cells
,null,
PLoS ONE
,PubMed ID 18320024
[HSPA8]
|
Documents
FAQs |
SDS |
Customer
Reviews
Loading...