Collagen type IV Bovine Protein
CNY 6,000.00
货期*
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Specifications
Product Data | |
Description | Collagen type IV bovine protein, 0.5 mg |
Species | Bovine |
Protein Source | Placenta |
Concentration | lot specific |
Purity | >98% pure (chromatographically and immunologically pure). |
Buffer | State: Liquid (sterile filtered) purified Ig fraction. Buffer System: 0.5 M Sodium Acetate, pH 4.5 containing 0, 01% Sodium Azide as preservative |
Preparation | Liquid (sterile filtered) purified Ig fraction. |
Applications | Suitable for use as a Control or Standard in indirect trapping ELISA for quantitation of antigen in serum using a standard curve, for Immunoprecipitation and for Western blotting |
Protein Description | This product has been prepared from Bovine Placenta and reacts with anti-Collagen Type IV. Reaction with anti-Collagen I, II, III, V or VI is negligible (typically less than 1% cross reactivity was detected by ELISA). |
Storage | Store the antibody undiluted at 2-8°C. |
Stability | Shelf life: 6 month from despatch. |
Reference Data | |
RefSeq | NP_001290039 |
Locus ID | 1282 |
Cytogenetics | 13q34 |
Synonyms | BSVD; BSVD1; COL4A1s; PADMAL; RATOR |
Summary | This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] |
Protein Pathways | ECM-receptor interaction, Focal adhesion, Pathways in cancer, Small cell lung cancer |
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