Glutaredoxin 1 (GLRX) (NM_001118890) Human Mass Spec Standard

Specifications

Product Data
Description	GLRX MS Standard C13 and N15-labeled recombinant protein (NP_001112362)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC225029
Predicted MW	11.8 kDa
Protein Sequence	Sequence Link (showhide) >RC225029 protein sequence Red=Cloning site Green=Tags(s) MAQEFVNCKIQPGKVVVFIKPTCPYCRRAQEILSQLPIKQGLLEFVDITATNHTNEIQDYLQQLTGARTV PRVFIGKDCIGGCSDLVSLQQSGELLTRLKQIGALQ TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_001112362
RefSeq Size	1093
RefSeq ORF	318
Synonyms	GRX; GRX1
Locus ID	2745
Cytogenetics	5q15
Summary	This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011]
Protein Families	Druggable Genome

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