TJP1 (NM_003257) Human Mass Spec Standard

CAT#: PH322836

TJP1 MS Standard C13 and N15-labeled recombinant protein (NP_003248)



  View other "TJP1" proteins (5)

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CNY 14,250.00


货期*
5周

规格
    • 10 ug

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Specifications

Product Data
Description TJP1 MS Standard C13 and N15-labeled recombinant protein (NP_003248)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC222836
Predicted MW 195.3 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_003248
RefSeq Size 7165
RefSeq ORF 5244
Synonyms ZO-1
Locus ID 7082
Cytogenetics 15q13.1
Summary This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, and acts as a tight junction adaptor protein that also regulates adherens junctions. Tight junctions regulate the movement of ions and macromolecules between endothelial and epithelial cells. The multidomain structure of this scaffold protein, including a postsynaptic density 95/disc-large/zona occludens (PDZ) domain, a Src homology (SH3) domain, a guanylate kinase (GuK) domain and unique (U) motifs all help to co-ordinate binding of transmembrane proteins, cytosolic proteins, and F-actin, which are required for tight junction function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
Protein Families Druggable Genome
Protein Pathways Adherens junction, Epithelial cell signaling in Helicobacter pylori infection, Gap junction, Tight junction, Vibrio cholerae infection
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