GIP (NM_004123) Human Mass Spec Standard

Specifications

Product Data
Description	GIP MS Standard C13 and N15-labeled recombinant protein (NP_004114)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC222456
Predicted MW	17.1 kDa
Protein Sequence	Sequence Link (showhide) >RC222456 protein sequence Red=Cloning site Green=Tags(s) MVATKTFALLLLSLFLAVGLGEKKEGHFSALPSLPVGSHAKVSSPQPRGPRYAEGTFISDYSIAMDKIHQ QDFVNWLLAQKGKKNDWKHNITQREARALELAGQANRKEEEAVEPQSSPAKNPSDEDLLRDLLIQELLAC LLDQTNLCRLRSR TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_004114
RefSeq Size	711
RefSeq ORF	459
Locus ID	2695
Cytogenetics	17q21.32
Summary	This gene encodes an incretin hormone and belongs to the glucagon superfamily. The encoded protein is important in maintaining glucose homeostasis as it is a potent stimulator of insulin secretion from pancreatic beta-cells following food ingestion and nutrient absorption. This gene stimulates insulin secretion via its G protein-coupled receptor activation of adenylyl cyclase and other signal transduction pathways. It is a relatively poor inhibitor of gastric acid secretion. [provided by RefSeq, Jul 2008]
Protein Families	Druggable Genome, Secreted Protein

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