Caveolin 3 (CAV3) (NM_033337) Human Mass Spec Standard

Specifications

Product Data
Description	CAV3 MS Standard C13 and N15-labeled recombinant protein (NP_203123)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC221140
Predicted MW	17.3 kDa
Protein Sequence	Sequence Link (showhide) >RC221140 protein sequence Red=Cloning site Green=Tags(s) MMAEEHTDLEAQIVKDIHCKEIDLVNRDPKNINEDIVKVDFEDVIAEPVGTYSFDGVWKVSYTTFTVSKY WCYRLLSTLLGVPLALLWGFLFACISFCHIWAVVPCIKSYLIEIQCISHIYSLCIRTFCNPLFAALGQVC SSIKVVLRKEV TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_203123
RefSeq Size	1435
RefSeq ORF	453
Synonyms	LGMD1C; LQT9; MPDT; RMD2; VIP-21; VIP21
Locus ID	859
Cytogenetics	3p25.3
Summary	This gene encodes a caveolin family member, which functions as a component of the caveolae plasma membranes found in most cell types. Caveolin proteins are proposed to be scaffolding proteins for organizing and concentrating certain caveolin-interacting molecules. Mutations identified in this gene lead to interference with protein oligomerization or intra-cellular routing, disrupting caveolae formation and resulting in Limb-Girdle muscular dystrophy type-1C (LGMD-1C), hyperCKemia or rippling muscle disease (RMD). Alternative splicing has been identified for this locus, with inclusion or exclusion of a differentially spliced intron. In addition, transcripts utilize multiple polyA sites and contain two potential translation initiation sites. [provided by RefSeq, Jul 2008]
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Focal adhesion

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