CAMLG (NM_001745) Human Mass Spec Standard

CAT#: PH318292

CAMLG MS Standard C13 and N15-labeled recombinant protein (NP_001736)



  View other "CAMLG" proteins (3)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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Specifications

Product Data
Description CAMLG MS Standard C13 and N15-labeled recombinant protein (NP_001736)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC218292
Predicted MW 33 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_001736
RefSeq Size 2255
RefSeq ORF 888
Synonyms CAML; GET2
Locus ID 819
Cytogenetics 5q31.1
Summary The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome
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