Glutaredoxin 2 (GLRX2) (NM_016066) Human Mass Spec Standard

Specifications

Product Data
Description	GLRX2 MS Standard C13 and N15-labeled recombinant protein (NP_057150)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC215566
Predicted MW	18.5 kDa
Protein Sequence	Sequence Link (showhide) >RC215566 representing NM_016066 Red=Cloning site Green=Tags(s) MNPRDKQVSRFSPLKDVYTWVALAGIQRSGSPGRTRSAARRMESNTSSSLENLATAPVNQIQETISDNCV VIFSKTSCSYCTMAKKLFHDMNVNYKVVELDLLEYGNQFQDALYKMTGERTVPRIFVNGTFIGGATDTHR LHKEGKLLPLVHQCYLKKSKRKEFQ TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_057150
RefSeq Size	1170
RefSeq ORF	495
Synonyms	CGI-133; GRX2
Locus ID	51022
Cytogenetics	1q31.2
Summary	The protein encoded by this gene is a member of the glutaredoxin family of proteins, which maintain cellular thiol homeostasis. These proteins are thiol-disulfide oxidoreductases that use a glutathione-binding site and one or two active cysteines in their active site. This gene undergoes alternative splicing to produce multiple isoforms, one of which is ubiquitously expressed and localizes to mitochondria, where it functions in mitochondrial redox homeostasis and is important for the protection against and recovery from oxidative stress. Other isoforms, which have more restrictive expression patterns, show cytosolic and nuclear localization, and are thought to function in cellular differentiation and transformation, possibly with a role in tumor progression. [provided by RefSeq, Aug 2011]
Protein Families	Transcription Factors

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