GADD45B (NM_015675) Human Mass Spec Standard

Specifications

Product Data
Description	GADD45B MS Standard C13 and N15-labeled recombinant protein (NP_056490)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC213354
Predicted MW	17.6 kDa
Protein Sequence	Sequence Link (showhide) >RC213354 representing NM_015675 Red=Cloning site Green=Tags(s) MTLEELVACDNAAQKMQTVTAAVEELLVAAQRQDRLTVGVYESAKLMNVDPDSVVLCLLAIDEEEEDDIA LQIHFTLIQSFCCDNDINIVRVSGNARLAQLLGEPAETQGTTEARDLHCLPFLQNPHTDAWKSHGLVEVA SYCEESRGNNQWVPYISLQER TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_056490
RefSeq Size	1121
RefSeq ORF	483
Synonyms	GADD45BETA; MYD118
Locus ID	4616
Cytogenetics	19p13.3
Summary	This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008]
Protein Families	Druggable Genome
Protein Pathways	Cell cycle, MAPK signaling pathway, p53 signaling pathway

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