Ikaros (IKZF1) (NM_006060) Human Mass Spec Standard

CAT#: PH313207

IKZF1 MS Standard C13 and N15-labeled recombinant protein (NP_006051)



  View other "Ikaros" proteins (3)

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CNY 14,250.00


货期*
5周

规格
    • 10 ug

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经常一起买 (2)
Transient overexpression lysate of IKAROS family zinc finger 1 (Ikaros) (IKZF1)
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Rabbit Polyclonal anti-IKZF1 antibody
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Specifications

Product Data
Description IKZF1 MS Standard C13 and N15-labeled recombinant protein (NP_006051)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC213207
Predicted MW 57.3 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_006051
RefSeq Size 3962
RefSeq ORF 1557
Synonyms CVID13; Hs.54452; IK1; IKAROS; LyF-1; LYF1; PPP1R92; PRO0758; ZNFN1A1
Locus ID 10320
Cytogenetics 7p12.2
Summary This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2014]
Protein Families Druggable Genome, Transcription Factors
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