FAM195B (MCRIP1) (NM_207368) Human Mass Spec Standard

Specifications

Product Data
Description	FAM195B MS Standard C13 and N15-labeled recombinant protein (NP_997251)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC211513
Predicted MW	10.7 kDa
Protein Sequence	Sequence Link (showhide) >RC211513 representing NM_207368 Red=Cloning site Green=Tags(s) MHGEKSHGRGQAGRQVPLKQQSVSGESQQGARQGAGQSTCYLSSAFLCNGSFPAGSMSLWDPQPKQAFPS VLWCSWAGVPGRRTGQRDPRVQERRGDFVSKLGAAVGGEPLALFGPHSWPGMGHRVPGLGAGFLLFAGFA LEPWDSYHVVFEGWTIDMRRNEPERTRSLSAPGPL TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_997251
RefSeq Size	2980
RefSeq ORF	525
Synonyms	FAM195B; GRAN2; MCRIP
Locus ID	348262
Cytogenetics	17q25.3
Summary	The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition (PubMed:25728771).[UniProtKB/Swiss-Prot Function]

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