Shwachman Bodian Diamond syndrome (SBDS) (NM_016038) Human Mass Spec Standard

Specifications

Product Data
Description	SBDS MS Standard C13 and N15-labeled recombinant protein (NP_057122)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC208964
Predicted MW	28.8 kDa
Protein Sequence	Sequence Link (showhide) >RC208964 protein sequence Red=Cloning site Green=Tags(s) MSIFTPTNQIRLTNVAVVRMKRAGKRFEIACYKNKVVGWRSGVEKDLDEVLQTHSVFVNVSKGQVAKKED LISAFGTDDQTEICKQILTKGEVQVSDKERHTQLEQMFRDIATIVADKCVNPETKRPYTVILIERAMKDI HYSVKTNKSTKQQALEVIKQLKEKMKIERAHMRLRFILPVNEGKKLKEKLKPLIKVIESEDYGQQLEIVC LIDPGCFREIDELIKKETKGKGSLEVLNLKDVEEGDEKFE TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_057122
RefSeq Size	1605
RefSeq ORF	750
Synonyms	CGI-97; SDO1; SDS; SWDS
Locus ID	51119
Cytogenetics	7q11.21
Summary	This gene encodes a highly conserved protein that plays an essential role in ribosome biogenesis. The encoded protein interacts with elongation factor-like GTPase 1 to disassociate eukaryotic initiation factor 6 from the late cytoplasmic pre-60S ribosomal subunit allowing assembly of the 80S subunit. Mutations within this gene are associated with the autosomal recessive disorder Shwachman-Bodian-Diamond syndrome. This gene has a closely linked pseudogene that is distally located. [provided by RefSeq, Jan 2017]

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