Kininogen 1 (KNG1) (NM_000893) Human Mass Spec Standard

CAT#: PH308879

KNG1 MS Standard C13 and N15-labeled recombinant protein (NP_000884)



  View other "Kininogen 1" proteins (6)

Need it in bulk or customized?
Get a free quote

CNY 19,520.00


货期*
4周

规格
    • 10 ug

Product images

经常一起买 (2)
Rabbit Polyclonal antibody to Kininogen 1 (kininogen 1)
    • 100 ul

CNY 6,281.00


Transient overexpression lysate of kininogen 1 (KNG1), transcript variant 3
    • 100 ug

CNY 3,080.00

Specifications

Product Data
Description KNG1 MS Standard C13 and N15-labeled recombinant protein (NP_000884)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC208879
Predicted MW 47.9 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_000884
RefSeq Size 2143
RefSeq ORF 1281
Synonyms BDK; BK; HAE6; HMWK; KNG
Locus ID 3827
Cytogenetics 3q27.3
Summary This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. Bradykinin also functions as an antimicrobial peptide with antibacterial and antifungal activity. In contrast to HMWK, LMWK is not involved in blood coagulation. Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reduces or depletes angiotensin converting enzyme 2 (ACE2), which results in an increase in levels of des-Arg(9)-bradykinin, a bioactive metabolite of bradykinin that is associated with lung injury and inflammation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2020]
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Complement and coagulation cascades
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Documents

Other Versions

Customer Reviews 
Loading...