Kininogen 1 (KNG1) (NM_000893) Human Mass Spec Standard
CAT#: PH308879
KNG1 MS Standard C13 and N15-labeled recombinant protein (NP_000884)
View other "Kininogen 1" proteins (6)
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CNY 19,520.00
Specifications
Product Data | |
Description | KNG1 MS Standard C13 and N15-labeled recombinant protein (NP_000884) |
Species | Human |
Expression Host | HEK293 |
Expression cDNA Clone or AA Sequence | RC208879 |
Predicted MW | 47.9 kDa |
Protein Sequence |
>RC208879 protein sequence
Red=Cloning site Green=Tags(s) MKLITILFLCSRLLLSLTQESQSEEIDCNDKDLFKAVDAALKKYNSQNQSNNQFVLYRITEATKTVGSDT FYSFKYEIKEGDCPVQSGKTWQDCEYKDAAKAATGECTATVGKRSSTKFSVATQTCQITPAEGPVVTAQY DCLGCVHPISTQSPDLEPILRHGIQYFNNNTQHSSLFMLNEVKRAQRQVVAGLNFRMTYSIVQTNCSKEN FLFLTPDCKSLWNGDTGECTDNAYIDIQLRIASFSQNCDIYPGKDFVQPPTKICVGCPRDIPTNSPELEE TLTHTITKLNAENNATFYFKIDNVKKARVQVVAGKKYFIDFVARETTCSKESNEELTESCETKKLGQSLD CNAEVYVVPWEKKIYPTVNCQPLGMISLMKRPPGFSPFRSSRIGEIKEETTSHLRSCEYKGRPPKAGAEP ASEREVS TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
Tag | C-Myc/DDK |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration | >0.05 µg/µL as determined by microplate BCA method |
Labeling Method | Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine |
Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3 |
Reference Data | |
RefSeq | NP_000884 |
RefSeq Size | 2143 |
RefSeq ORF | 1281 |
Synonyms | BDK; BK; HAE6; HMWK; KNG |
Locus ID | 3827 |
Cytogenetics | 3q27.3 |
Summary | This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. Bradykinin also functions as an antimicrobial peptide with antibacterial and antifungal activity. In contrast to HMWK, LMWK is not involved in blood coagulation. Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reduces or depletes angiotensin converting enzyme 2 (ACE2), which results in an increase in levels of des-Arg(9)-bradykinin, a bioactive metabolite of bradykinin that is associated with lung injury and inflammation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2020] |
Protein Families | Druggable Genome, Secreted Protein |
Protein Pathways | Complement and coagulation cascades |
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
LC400319 | KNG1 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
LC432983 | KNG1 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
LY400319 | Transient overexpression lysate of kininogen 1 (KNG1), transcript variant 2 |
CNY 3,080.00 |
|
LY432983 | Transient overexpression lysate of kininogen 1 (KNG1), transcript variant 3 |
CNY 3,080.00 |
|
TP308879 | Recombinant protein of human kininogen 1 (KNG1), transcript variant 2, 20 µg |
CNY 2,900.00 |
|
TP720432 | Recombinant protein of human kininogen 1 (KNG1), transcript variant 2 |
CNY 3,140.00 |
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