Pellino 1 (PELI1) (NM_020651) Human Mass Spec Standard

CAT#: PH308197

PELI1 MS Standard C13 and N15-labeled recombinant protein (NP_065702)



  View other "Pellino 1" proteins (3)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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Specifications

Product Data
Description PELI1 MS Standard C13 and N15-labeled recombinant protein (NP_065702)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC208197
Predicted MW 46.3 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_065702
RefSeq Size 3780
RefSeq ORF 1254
Locus ID 57162
Cytogenetics 2p14
Summary E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (PubMed:12496252, PubMed:17675297). Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3 (PubMed:29883609). Negatively regulates necroptosis by reducing RIPK3 expression (PubMed:29883609). Mediates 'Lys-63'-linked ubiquitination of RIPK1 (PubMed:29883609).[UniProtKB/Swiss-Prot Function]
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