CIPC (NM_033426) Human Mass Spec Standard

Specifications

Product Data
Description	KIAA1737 MS Standard C13 and N15-labeled recombinant protein (NP_219494)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC206226
Predicted MW	42.7 kDa
Protein Sequence	Sequence Link (showhide) >RC206226 protein sequence Red=Cloning site Green=Tags(s) MERKNPSRESPRRLSAKVGKGTEMKKVARQFGMAAAESDKDSGFSDGSSECLSSAEQMESEDMLSALGWS REDRPRQNSKTAKNAFPTLSPMVVMKNVLVKQGSSSSQLQSWTVQPSFEVISAQPQLLFLHPPVPSPVSP CHTGEKKSDSRNYLPILNSYTKIAPHPGKRGLSLGPEEKGTSGVQKKICTERLGPSLSSSEPTKAGAVPS SPSTPAPPSAKLAEDSALQGVPSLVAGGSPQTLQPVSSSHVAKAPSLTFASPASPVCASDSTLHGLESNS PLSPLSANYSSPLWAAEHLCRSPDIFSEQRQSKHRRFQNTLVVLHKSGLLEITLKTKELIRQNQATQVEL DQLKEQTQLFIEATKSRAPQAWAKLQASLTPGSSNTGSDLEAFSDHPAI TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_219494
RefSeq Size	4397
RefSeq ORF	1197
Synonyms	KIAA1737
Locus ID	85457
Cytogenetics	14q24.3
Summary	Transcriptional repressor which may act as a negative-feedback regulator of CLOCK-ARNTL/BMAL1 transcriptional activity in the circadian-clock mechanism. May stimulate ARNTL/BMAL1-dependent phosphorylation of CLOCK. However, the physiogical relevance of these observations is unsure, since experiments in an animal model showed that CIPC is not critially required for basic circadian clock.[UniProtKB/Swiss-Prot Function]

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