Metallothionein (MT1A) (NM_005946) Human Mass Spec Standard

Specifications

Product Data
Description	MT1A MS Standard C13 and N15-labeled recombinant protein (NP_005937)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC205942
Predicted MW	6.1 kDa
Protein Sequence	Sequence Link (showhide) >RC205942 protein sequence Red=Cloning site Green=Tags(s) MDPNCSCATGGSCTCTGSCKCKECKCNSCKKSCCSCCPMSCAKCAQGCICKGASEKCSCCA TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_005937
RefSeq Size	468
RefSeq ORF	183
Synonyms	MT-1A; MT-IA; MT1; MT1S; MTC
Locus ID	4489
Cytogenetics	16q13
Summary	This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. The conserved cysteine residues co-ordinate metal ions using mercaptide linkages. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals. Disruption of two metallothionein genes in mouse resulted in defects in protection against heavy metals, oxidative stress, immune reactions, carcinogens, and displayed obesity. [provided by RefSeq, Sep 2017]

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