ACN9 (SDHAF3) (NM_020186) Human Mass Spec Standard

Specifications

Product Data
Description	ACN9 MS Standard C13 and N15-labeled recombinant protein (NP_064571)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC204626
Predicted MW	14.7 kDa
Protein Sequence	Sequence Link (showhide) >RC204626 protein sequence Red=Cloning site Green=Tags(s) MPGRHVSRVRALYKRVLQLHRVLPPDLKSLGDQYVKDEFRRHKTVGSDEAQRFLQEWEVYATALLQQANE NRQNSTGKACFGTFLPEEKLNDFRDEQIGQLQELMQEATKPNRQFSISESMKPKF TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_064571
RefSeq Size	2068
RefSeq ORF	375
Synonyms	ACN9; DC11; LYRM10; Sdh7
Locus ID	57001
Cytogenetics	7q21.3
Summary	Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.[UniProtKB/Swiss-Prot Function]

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