HEPC (HAMP) (NM_021175) Human Mass Spec Standard

Specifications

Product Data
Description	HAMP MS Standard C13 and N15-labeled recombinant protein (NP_066998)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC204620
Predicted MW	9.4 kDa
Protein Sequence	Sequence Link (showhide) >RC204620 protein sequence Red=Cloning site Green=Tags(s) MALSSQIWAACLLLLLLLASLTSGSVFPQQTGQLAELQPQDRAGARASWMPMFQRRRRRDTHFPICIFCC GCCHRSKCGMCCKT TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_066998
RefSeq Size	430
RefSeq ORF	252
Synonyms	HEPC; HFE2B; LEAP1; PLTR
Locus ID	57817
Cytogenetics	19q13.12
Summary	The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity against bacteria and fungi. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. [provided by RefSeq, Oct 2014]
Protein Families	Secreted Protein, Transmembrane

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