Tcl1 (TCL1A) (NM_021966) Human Mass Spec Standard

CAT#: PH304243

TCL1A MS Standard C13 and N15-labeled recombinant protein (NP_068801)



  View other "Tcl1" proteins (8)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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Specifications

Product Data
Description TCL1A MS Standard C13 and N15-labeled recombinant protein (NP_068801)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC204243
Predicted MW 13.5 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_068801
RefSeq Size 1410
RefSeq ORF 342
Synonyms TCL1
Locus ID 8115
Cytogenetics 14q32.13
Summary Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]
Protein Families Druggable Genome
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