PCBD1 (NM_000281) Human Mass Spec Standard

Specifications

Product Data
Description	PCBD1 MS Standard C13 and N15-labeled recombinant protein (NP_000272)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC202880
Predicted MW	12 kDa
Protein Sequence	Sequence Link (showhide) >RC202880 protein sequence Red=Cloning site Green=Tags(s) MAGKAHRLSAEERDQLLPNLRAVGWNELEGRDAIFKQFHFKDFNRAFGFMTRVALQAEKLDHHPEWFNVY NKVHITLSTHECAGLSERDINLASFIEQVAVSMT TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_000272
RefSeq Size	1019
RefSeq ORF	312
Synonyms	DCOH; PCBD; PCD; PHS
Locus ID	5092
Cytogenetics	10q22.1
Summary	This gene encodes a member of the pterin-4-alpha-carbinolamine dehydratase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein functions as both a dehydratase involved in tetrahydrobiopterin biosynthesis, and as a cofactor for HNF1A-dependent transcription. A deficiency of this enzyme leads to hyperphenylalaninemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Protein Families	Druggable Genome

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