Apolipoprotein CII (APOC2) (NM_000483) Human Mass Spec Standard

Specifications

Product Data
Description	APOC2 MS Standard C13 and N15-labeled recombinant protein (NP_000474)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC202771
Predicted MW	11.2 kDa
Protein Sequence	Sequence Link (showhide) >RC202771 protein sequence Red=Cloning site Green=Tags(s) MGTRLLPALFLVLLVLGFEVQGTQQPQQDEMPSPTLLTQVKESLSSYWESAKTAAQNLYEKTYLPAVDEK LRDLYSKSTAAMSTYTGIFTDQVLSVLKGEE TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_000474
RefSeq Size	738
RefSeq ORF	303
Synonyms	APO-CII; APOC-II
Locus ID	344
Cytogenetics	19q13.32
Summary	This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene. [provided by RefSeq, Mar 2011]
Protein Families	Druggable Genome, Secreted Protein

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