PIH1D1 (NM_017916) Human Mass Spec Standard

Specifications

Product Data
Description	PIH1D1 MS Standard C13 and N15-labeled recombinant protein (NP_060386)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC200158
Predicted MW	32.4 kDa
Protein Sequence	Sequence Link (showhide) >RC200158 protein sequence Red=Cloning site Green=Tags(s) MANPKLLGLELSEAEAIGADSARFEELLLQASKELQQAQTTRPESTQIQPQPGFCIKTNSSEGKVFINIC HSPSIPPPADVTEEELLQMLEEDQAGFRIPMSLGEPHAELDAKGQGCTAYDVAVNSDFYRRMQNSDFLRE LVITIAREGLEDKYNLQLNPEWRMMKNRPFMGSISQQNIRSEQRPRIQELGDLYTPAPGRAESGPEKPHL NLWLEAPDLLLAEIDLPKLDGALGLSLEIGENRLVMGGPQQLYHLDAYIPLQINSHESKAAFHRKRKQLM VAMPLLLVPS TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_060386
RefSeq Size	1256
RefSeq ORF	870
Synonyms	MOT48; NOP17; Pih1
Locus ID	55011
Cytogenetics	19q13.33
Summary	Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles (PubMed:17636026). Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription (PubMed:22368283, PubMed:24036451). Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 (PubMed:20864032). Positively regulates the assembly and activity of the mTORC1 complex (PubMed:24036451).[UniProtKB/Swiss-Prot Function]
Protein Families	Druggable Genome

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