Wdr45 Mouse Gene Knockout Kit (CRISPR)

Specifications

Product Data
Format	2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
Donor DNA	mBFP-Neo
Symbol	Wdr45
Locus ID	54636
Kit Components	KN319361G1, Wdr45 gRNA vector 1 in pCas-Guide CRISPR vector KN319361G2, Wdr45 gRNA vector 2 in pCas-Guide CRISPR vector KN319361BN-D, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette. GE100003, scramble sequence in pCas-Guide vector
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq	NM_001290792, NM_001290794, NM_001290795, NM_172372
Synonyms	C79260; DXImx38e; JM5; Sfc19; Wdrx1; WIPI-4
Summary	Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes. Probably recruited to membranes through its PtdIns3P activity.[UniProtKB/Swiss-Prot Function]

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