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E2f7 (NM_001108092) Rat Tagged ORF Clone Lentiviral Particle
CAT＃: RR211801L4V
- LentiORF®
-
Lenti ORF particles, E2f7 (GFP-tagged ORF) - Rat E2F transcription factor 7 (E2f7), 200ul, >10^7 TU/mL
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CNY 10,830.00
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Specifications
| Product Data | |
| Product Name | E2f7 (NM_001108092) Rat Tagged ORF Clone Lentiviral Particle |
| Synonyms | E2F-7 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_001108092 |
| ORF Size | 1542 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RR211801).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001108092.1, NP_001101562.1 |
| RefSeq Size | 3369 bp |
| RefSeq ORF | 1545 bp |
| Locus ID | 314818 |
| Gene Summary | Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Acts as a negative regulator of keratinocyte differentiation (By similarity).[UniProtKB/Swiss-Prot Function] |
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