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Traf6 (NM_001107754) Rat Tagged ORF Clone Lentiviral Particle
CAT＃: RR211042L4V
- LentiORF®
-
Lenti ORF particles, Traf6 (GFP-tagged ORF) - Rat Tnf receptor-associated factor 6 (Traf6), 200ul, >10^7 TU/mL
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CNY 11,020.00
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Specifications
| Product Data | |
| Product Name | Traf6 (NM_001107754) Rat Tagged ORF Clone Lentiviral Particle |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_001107754 |
| ORF Size | 1590 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RR211042).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001107754.2, NP_001101224.1 |
| RefSeq Size | 2753 bp |
| RefSeq ORF | 1593 bp |
| Locus ID | 311245 |
| Gene Summary | E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.[UniProtKB/Swiss-Prot Function] |
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