Usp16 (NM_001100501) Rat Tagged ORF Clone Lentiviral Particle
CAT#: RR209366L3V
- LentiORF®
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Lenti ORF particles, Usp16 (Myc-DDK-tagged ORF) - Rat ubiquitin specific peptidase 16 (Usp16), 200ul, >10^7 TU/mL
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CNY 13,215.00
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Specifications
Product Data | |
Product Name | Usp16 (NM_001100501) Rat Tagged ORF Clone Lentiviral Particle |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
ACCN | NM_001100501 |
ORF Size | 2475 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RR209366).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_001100501.1, NP_001093971.1 |
RefSeq Size | 2903 bp |
RefSeq ORF | 2478 bp |
Locus ID | 288306 |
Gene Summary | Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.[UniProtKB/Swiss-Prot Function] |
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