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Mical1 (NM_001106397) Rat Tagged ORF Clone Lentiviral Particle
CAT＃: RR206110L3V
- LentiORF®
-
Lenti ORF particles, Mical1 (Myc-DDK-tagged ORF) - Rat microtubule associated monoxygenase, calponin and LIM domain containing 1 (Mical1), 200ul, >10^7 TU/mL
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CNY 18,734.00
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Specifications
| Product Data | |
| Product Name | Mical1 (NM_001106397) Rat Tagged ORF Clone Lentiviral Particle |
| Synonyms | MICAL-1; Nical |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_001106397 |
| ORF Size | 3141 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RR206110).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001106397.1, NP_001099867.1 |
| RefSeq Size | 3536 bp |
| RefSeq ORF | 3144 bp |
| Locus ID | 294520 |
| Gene Summary | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels. May act as Rab effector protein and play a role in vesicle trafficking.[UniProtKB/Swiss-Prot Function] |
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