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Mob1a (NM_001033891) Rat Tagged ORF Clone Lentiviral Particle
CAT＃: RR205096L3V
- LentiORF®
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Lenti ORF particles, Mob1a (Myc-DDK-tagged ORF) - Rat MOB1, Mps One Binder kinase activator-like 1B (yeast) (Mobkl1b), 200ul, >10^7 TU/mL
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CNY 7,410.00
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Specifications
| Product Data | |
| Product Name | Mob1a (NM_001033891) Rat Tagged ORF Clone Lentiviral Particle |
| Synonyms | Mobk1b; Mobkl1b |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_001033891 |
| ORF Size | 648 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RR205096).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001033891.1, NP_001029063.1 |
| RefSeq Size | 4480 bp |
| RefSeq ORF | 651 bp |
| Locus ID | 297387 |
| Gene Summary | Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38 (By similarity).[UniProtKB/Swiss-Prot Function] |
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