Tnfrsf21 (NM_001108207) Rat Tagged ORF Clone Lentiviral Particle
CAT#: RR204317L3V
- LentiORF®
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Lenti ORF particles, Tnfrsf21 (Myc-DDK-tagged ORF) - Rat tumor necrosis factor receptor superfamily, member 21 (Tnfrsf21), 200ul, >10^7 TU/mL
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CNY 11,277.00
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Specifications
Product Data | |
Product Name | Tnfrsf21 (NM_001108207) Rat Tagged ORF Clone Lentiviral Particle |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
ACCN | NM_001108207 |
ORF Size | 1965 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RR204317).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_001108207.1, NP_001101677.1 |
RefSeq Size | 4350 bp |
RefSeq ORF | 1968 bp |
Locus ID | 316256 |
Gene Summary | Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation (By similarity). Negatively regulates oligodendrocyte survival, maturation and myelination.[UniProtKB/Swiss-Prot Function] |
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