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SynGAP (SYNGAP1) (NM_006772) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC229432L2V
- LentiORF®
-
Lenti ORF particles, SYNGAP1 (mGFP-tagged)-Human synaptic Ras GTPase activating protein 1 (SYNGAP1), 200ul, >10^7 TU/mL
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CNY 24,035.00
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Specifications
| Product Data | |
| Product Name | SynGAP (SYNGAP1) (NM_006772) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | MRD5; RASA1; RASA5; SYNGAP |
| Vector | pLenti-C-mGFP |
| ACCN | NM_006772 |
| ORF Size | 4029 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC229432).
|
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_006772.2 |
| RefSeq ORF | 4032 bp |
| Locus ID | 8831 |
| Protein Families | Druggable Genome |
| MW | 148.1 kDa |
| Gene Summary | This gene encodes a Ras GTPase activating protein that is a member of the N-methyl-D-aspartate receptor complex. The N-terminal domain of the protein contains a Ras-GAP domain, a pleckstrin homology domain, and a C2 domain that may be involved in binding of calcium and phospholipids. The C-terminal domain consists of a ten histidine repeat region, serine and tyrosine phosphorylation sites, and a T/SXV motif required for postsynaptic scaffold protein interaction. The encoded protein negatively regulates Ras, Rap and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking to the postsynaptic membrane to regulate synaptic plasticity and neuronal homeostasis. Allelic variants of this gene are associated with intellectual disability and autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016] |
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