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MLKL (NM_001142497) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC227973L4V
- LentiORF®
-
Lenti ORF particles, MLKL (mGFP-tagged)-Human mixed lineage kinase domain-like (MLKL), transcript variant 2, 200ul, >10^7 TU/mL
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CNY 9,405.00
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| Product Data | |
| Product Name | MLKL (NM_001142497) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | hMLKL |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_001142497 |
| ORF Size | 789 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC227973).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001142497.1 |
| RefSeq ORF | 792 bp |
| Locus ID | 197259 |
| Protein Families | Druggable Genome, Protein Kinase |
| MW | 30.1 kDa |
| Gene Summary | This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015] |
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