TRAF4AF1 (KNSTRN) (NM_001142761) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC227397L3V
- LentiORF®
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Lenti ORF particles, KNSTRN (Myc-DDK tagged) - Human chromosome 15 open reading frame 23 (C15orf23), transcript variant 2, 200ul, >10^7 TU/mL
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CNY 8,170.00
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规格
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Specifications
Product Data | |
Product Name | TRAF4AF1 (KNSTRN) (NM_001142761) Human Tagged ORF Clone Lentiviral Particle |
Synonyms | C15orf23; HSD11; SKAP; TRAF4AF1 |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
ACCN | NM_001142761 |
ORF Size | 858 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC227397).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_001142761.1, NP_001136233.1 |
RefSeq ORF | 861 bp |
Locus ID | 90417 |
MW | 31.7 kDa |
Gene Summary | Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase (PubMed:19667759). Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:19667759, PubMed:22110139). The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments (PubMed:21402792). Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division (PubMed:23035123). May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidences (PubMed:24718257).[UniProtKB/Swiss-Prot Function] |
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