MOV10 (NM_001130079) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC226296L3V
- LentiORF®
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Lenti ORF particles, MOV10 (Myc-DDK tagged) - Human Mov10, Moloney leukemia virus 10, homolog (mouse) (MOV10), transcript variant 2, 200ul, >10^7 TU/mL
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CNY 11,210.00
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Specifications
Product Data | |
Product Name | MOV10 (NM_001130079) Human Tagged ORF Clone Lentiviral Particle |
Synonyms | fSAP113; gb110 |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
ACCN | NM_001130079 |
ORF Size | 3009 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC226296).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_001130079.1, NP_001123551.1 |
RefSeq Size | 3491 bp |
RefSeq ORF | 3012 bp |
Locus ID | 4343 |
MW | 113.7 kDa |
Gene Summary | 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs (PubMed:24726324). Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:16289642, PubMed:17507929, PubMed:22791714). In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2 (PubMed:25464849). Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1 (PubMed:30122351, PubMed:23093941). Facilitates LINE-1 uridylation by TUT4 and TUT7 (PubMed:30122351). Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol (By similarity). May function as a messenger ribonucleoprotein (mRNP) clearance factor (PubMed:24726324).[UniProtKB/Swiss-Prot Function] |
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