C10orf90 (NM_001004298) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC223255L4V
- LentiORF®
Lenti ORF particles, C10orf90 (mGFP-tagged) - Human chromosome 10 open reading frame 90 (C10orf90), 200ul, >10^7 TU/mL
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CNY 9,975.00
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Specifications
Product Data | |
Product Name | C10orf90 (NM_001004298) Human Tagged ORF Clone Lentiviral Particle |
Synonyms | bA422P15.2; FATS |
Vector | pLenti-C-mGFP-P2A-Puro |
ACCN | NM_001004298 |
ORF Size | 2097 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC223255).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_001004298.2 |
RefSeq Size | 3097 bp |
RefSeq ORF | 2100 bp |
Locus ID | 118611 |
MW | 77.7 kDa |
Gene Summary | Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage. Acts as a p53/TP53 activator by inhibiting MDM2 binding to p53/TP53 and stimulating non-proteolytic polyubiquitination of p53/TP53. Exhibits ubiquitin ligase (E3) activity and assemble ubiquitin polymers through 'Lys-11'- (K11-), 'Lys-29'- (K29-) and 'Lys-63'- (K63)-linkages, independently of the ubiquitin-conjugating enzyme (E2). Promotes p53/TP53-dependent transcription of CDKN1A/p21, leading to robust checkpoint response. Mediates CDKN1A/p21 protein stability in a ubiquitin-independent manner. Interacts with HDAC1 and prevents binding of HDAC1 to CDKN1A/p21 and facilitates the acetylation and stabilization of CDKN1A/p21 (By similarity). May have a role in the assembly of primary cilia (Probable).[UniProtKB/Swiss-Prot Function] |
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