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Hairless (HR) (NM_018411) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC221977L3V
- LentiORF®
-
Lenti ORF particles, HR (Myc-DDK tagged) - Human hairless homolog (mouse) (HR), transcript variant 2, 200ul, >10^7 TU/mL
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CNY 19,285.00
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CNY 1,999.00
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Specifications
| Product Data | |
| Product Name | Hairless (HR) (NM_018411) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | ALUNC; AU; HSA277165; HYPT4; MUHH; MUHH1 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_018411 |
| ORF Size | 3402 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC221977).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_018411.3, NP_060881.2 |
| RefSeq Size | 4816 bp |
| RefSeq ORF | 3405 bp |
| Locus ID | 55806 |
| Protein Families | Druggable Genome, Transcription Factors |
| MW | 121.7 kDa |
| Gene Summary | This gene encodes a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including thyroid hormone receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of this protein is modulated by a regulatory open reading frame (ORF) that exists upstream of the primary ORF. Mutations in this upstream ORF cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant form of genetic hair loss. Mutations in this gene also cause autosomal recessive congenital alopecia and atrichia with papular lesions, other diseases resulting in hair loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014] |
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