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Cytochrome P450 2D6 (CYP2D6) (NM_001025161) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC221660L4V
- LentiORF®
-
Lenti ORF particles, CYP2D6 (mGFP-tagged) - Human cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D6), transcript variant 2, 200ul, >10^7 TU/mL
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CNY 9,975.00
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Specifications
| Product Data | |
| Product Name | Cytochrome P450 2D6 (CYP2D6) (NM_001025161) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | CPD6; CYP2D; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; CYP2DL1; CYPIID6; P450-DB1; P450C2D; P450DB1 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_001025161 |
| ORF Size | 1338 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC221660).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001025161.1 |
| RefSeq Size | 1520 bp |
| RefSeq ORF | 1341 bp |
| Locus ID | 1565 |
| Protein Families | Druggable Genome, P450, Transmembrane |
| Protein Pathways | Drug metabolism - cytochrome P450 |
| MW | 50.1 kDa |
| Gene Summary | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in copy number and individuals with the ultrarapid metabolizer phenotype can have 3 or more active copies of the gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014] |
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