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FCHSD2 (NM_014824) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC221241L3V
- LentiORF®
-
Lenti ORF particles, FCHSD2 (Myc-DDK tagged) - Human FCH and double SH3 domains 2 (FCHSD2), 200ul, >10^7 TU/mL
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CNY 13,870.00
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Specifications
| Product Data | |
| Product Name | FCHSD2 (NM_014824) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | NWK; NWK1; SH3MD3 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_014824 |
| ORF Size | 2052 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC221241).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_014824.1, NP_055639.1 |
| RefSeq Size | 4341 bp |
| RefSeq ORF | 2223 bp |
| Locus ID | 9873 |
| Domains | SH3 |
| MW | 77.6 kDa |
| Gene Summary | Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling (PubMed:30249660). Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits (PubMed:29887380). Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (PubMed:29887380). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes (PubMed:29887380).[UniProtKB/Swiss-Prot Function] |
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